Efficacy of antibiotic suppressive therapy in patients with a. Clindamycin 150450 mg po q6 hours x 10 days or 4800 mg iv daily beginning with 150 mg initial rapid infusion. The geisinger antimicrobial stewardship program handbook. Clindamycin is recommended as an alternative therapy for cutaneous anthrax infection. Oneil on clindamycin hcl 300 mg capsule side effects. Find patient medical information for clindamycin injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Children weighing 10 kilograms kg or moredose is based on body weight and must be determined by your doctor. Clindamycin is widely distributed in body fluids and. Prophylactic singledose administration of 600 mg clindamycin. Apr 07, 2020 cleocin phosphate iv solution in the galaxy plastic container for intravenous use is composed of clindamycin phosphate equivalent to 300, 600 and 900 mg of clindamycin premixed with 5% dextrose as a sterile solution. In this model, clindamycin administered at a low dose in an extendedinterval regimen 300 mg q12h exhibited antibacterial activity equivalent to that of the 300 or 600 mg q8h regimen. Clindamycin hydrochloride capsules, usp contain clindamycin hydrochloride, usp equivalent to 150 mg or 300 mg of clindamycin. Use with ceftriaxone or cefoxitinprobenecid if no proceeding iv treatment. By deep intramuscular injection, or by intravenous infusion. Population pharmacokinetics of clindamycin orally and. Clindamycin is marketed as generic and under trade names including cleocin hcl, clindacin, dalacin, evoclin and lincocin bangladesh. Clindac clindamycin ampoules are not for multiple dosing and any unused portion must be discarded. V 600 900 mg every 8 hours osteomyelitis due to mrsa unlabeled use. It is used to treat infections caused by organisms susceptible to clindamycin eg susceptible anaerobic bacteria susceptible strains of aerobic grampositive bacteria streptococci, staphylococci, pneumococci and susceptible strains chlamydia trachomatis.
I took mg zithromax yesterday, along with 450 mg clindamycin. Doxycyline 100 mg po bid or clindamycin 300 mg po tid or m upirocin ointment tid x 7d erysipelas. Cleocin, clindesse clindamycin dosing, indications, interactions. Cellulitis possibly due to mrsa unlabled use 300450mg po q8hr x 510 days. Dailymed clindamycin clindamycin phosphate injection, solution. Clindamycin was given at the dose of 600 mg every 12 hours for 7 days.
Alternatives to vancomycin and clindamycin include the following. Clindamycin 600mg4ml solution for injection ampoules 150mg. Doctors give trusted answers on uses, effects, sideeffects, and cautions. When the equivalent of 300 mg of clindamycin is injected intramuscularly, a mean peak plasma concentration of 6 microgramml is achieved within three hours. This web page contains comprehensive information about ndc code 1747812150. Clindamycin 150450 mg po q6 hours x 10 days or 4800 mg iv daily beginning with 150 mg initial rapid infusion, followed by continuous infusion q 24hours for 7days. Clindamycin phosphate bp equivalent to clindamycin 600mg4ml ampoule. Clindamycin as clindamycin phosphate 150 mg benzyl alcohol 9 mg edetate disodium water for injection. Penicillin allergy clindamycin po 450 600mg qds or iv 600mg qds if vomiting from medicine 911 at eastern virginia medical school. Manufacturers of clindamycin that have been granted an ndc national drug code.
Clindamycin 600 mg iv q8h covers camrsa if no inducible clindamycin resistance or cefazolin 1 g iv q8h. Single im injections of greater than 600 mg are not. In renal failure, reduce dose to a quarter or a third of the normal dose. Treat for 7 to 10 days for naturally acquired infection and for up to 60 days for a bioterrorismrelated event. Pharmacokinetics and pharmacodynamics of fosmidomycin. Clindamycin film coated tablets batch number 16843007 were supplied by alphamed pharbil arzneimittel gmbh. Evaluation of lowdose, extendedinterval clindamycin. How many capsules of clindamycin hydrochloride should be used to prepare 30 ml of the following preparation, if each capsule contains 150mg of clindamycin hydrochloride. Patients received 600 mg clindamycin as a tablet or intravenous i. Dilute medication in 100ml of ns and infuse over 90 minutes. For dosages that cannot be achieved with clindamycin stada 600 mg hard capsules. Clindamycin 600 mg orally 1 hour prior to the dental procedure patients allergic to penicillin and clindamycin 600 mg iv 1 hour prior to the dental procedure no second doses are recommended for any of these dosing regimens. Activities of clindamycin, daptomycin, doxycycline.
Despite over 25 years of widespread clinical use, clindamycin. For mild infections, it can be given at 300400 mg po qid or 450 mg tid. Clindamycin 450 mg tds oral clindamycin 600 mg tds oral or 600 mg qds iv or. Penicillin allergy clindamycin po 450 600mg qds or iv. Clindamycin ratiopharm 600 mg, 12, 14, 28 and 30 tablets clindamycin sandoz 150 mg ml, injectable solution clindamycin sandoz 300 mg, 12, 30 and 60 capsules clindamycin sandoz 450 mg, 12 and 30 tablets clindamycin sandoz 600 mg, 12, 14, 28 and 30 tablets clindamycin 1 a pharma 300 mg, 12 and 30 capsules clindamycin 1 a pharma 450 mg, 12 and 30. Clindamycin dosage modification may not be necessary in patients with renal. The synergism of 1599 with clindamycin, clarithromycin, and. The recommended dose of clindamycin capsules is between 600 and 1,800 mg daily, depending on the severity of your infection, every 6 to 8 hours. Apr 01, 2020 clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. The dose is usually 8 to 16 milligrams mg per kilogram kg of body weight per day, divided into 3 or 4 equal doses.
East and antibiotic usage flow chartnorth hertmild po coamoxiclav 625mg tds po clindamycin if penicillin allergic 300mg qds duration of treatment 710 days initially discharge and arrange out patient follow up with the diabetic podiatry clinic should be seen in the following weekmoderate iv coamoxiclav 1. Iv meropenem 1g tds if severe allergy discuss with microbiologist on call or iv clindamycin 600mg 1. Clindamycin remains a viable option for treating camrsa, as it demonstrates in. Oral clindamycin 300 mg bid compared with oral amoxicillinclavulanic acid 1 g bid in the outpatient treatment of acute recurrent. Prophylactic singledose administration of 600 mg clindamycin versus 4time administration of 600 mg clindamycin in orthognathic surgery. Following parenteral administration, the biologically inactive clindamycin phosphate is hydrolysed to clindamycin.
But i have pain in veins, itchy in throat and generally feel horrible. Because of the potential for serious adverse reactions in nursing infants, clindamycin. Determine the percentage of change and state the course of action. Hydroxychloroquine 200 mg po q 8 hrs 600 mg qd for a total of 10days. Reproduction studies performed in rats and mice using oral doses of clindamycin up to 600 mg kgday 3. In vitro and in vivo evaluation of synergism between antitubercular. Mirclindamycin 600 mg is an antibiotic from the group of lincosamides. Directions determine the following in drops per minute using. Because of the potential for serious adverse reactions in nursing infants, clindamycin should not be taken by nursing mothers. Clindamycin aka clindamycin phosphate is a human prescription drug product labeled by akorn, inc. Clindamycin ratiopharm 600 mg, 12, 14, 28 and 30 tablets clindamycin sandoz 150 mg ml, injectable solution clindamycin sandoz 300 mg, 12, 30 and 60 capsules clindamycin sandoz 450 mg, 12 and 30 tablets clindamycin sandoz 600 mg, 12, 14, 28 and 30 tablets clindamycin 1 a pharma 300 mg, 12 and 30 capsules clindamycin 1 a pharma 450 mg. If given intravenously, must be diluted before use. This suppression occurred with an ic 50 value of 18. The bioavailability is nonlinear and decreases with increasing doses.
Allergies are also frequent and often require discontinuation. Clinical practice guidelines by the infectious diseases society of. Clindamycin concentrations were monitored on a routine basis. Guidelines for treatment of skin and soft tissue infections. Marketing authorisation holder actavis group ptc ehf. Dailymed clindamycin clindamycin phosphate injection. Clindamycin hcl 300 mg capsule side effects answers on. It is used to treat infections caused by organisms susceptible to clindamycin eg susceptible anaerobic bacteria susceptible strains of aerobic grampositive bacteria streptococci, staphylococci. Clindamycin oral capsule is a prescription medication thats used to treat bacterial infections. Cerebral toxoplasmosis in rscm hospital jakarta clindamycin 600 mg qd po. Antibiotics, clindamycin, 150 600 mg po tid or 600mg iv q8h. Find clindamycin at best price offered by clindamycin manufacturers, clindamycin suppliers, dealers, traders and exporters. Clindamycin is a semisynthetic antibiotic produced by a 7schlorosubstitution of the 7rhydroxyl group of the parent compound lincomycin.
I took 250 mg zithromax today and 300 mg clindamycin. A prospective randomized study in bilateral mandibular sagittal ramus osteotomies. Nov 06, 2019 clindamycin has been reported to appear in breast milk in the range of 0. Clindamycin and nicotinic neuromuscular transmission. Clindamycin 600mg4ml solution for injection ampoules. If penicillin allergic, clindamycin 450 600 mg qds i. Clindamycin is given iv at 600900 mg q8hr for severe infections.
It is often less expensive to use twice as many 150 mg capsules rather than the clindamycin hcl 300 mg capsules. Oral clindamycin 300 mg bid compared with oral amoxicillin. Clindamycin 600 mg orally 1 hour prior to the dental procedure patients allergic to penicillin and clindamycin 600 mg iv 1 hour prior to the dental procedure no second. Population pharmacokinetics of clindamycin orally and 75006. Dalacin c clindamycin 600 mg sterile solution 4 ml 150 mg ml. May adjust dose as necessary not to exceed 40 mg kgday. Disodium edetate has been added at a concentration of 0. The peak plasma concentration is achieved within approximately 45 minutes after oral administration. These infections include acne and bacterial vaginosis.
Administer cleocin 600 mg bid iv for 7 days available. Clindamycin has been reported to appear in breast milk in the range of 0. This medicine is a colorless, clear, solution back to gallery. Activities of clindamycin, daptomycin, doxycycline, linezolid. After mice were inoculated, they were treated with 300 mg kg of clindamycin every 8 h q8h, 50 mg kg of daptomycin every day q. What clindamycin capsules look like and contents of the pack clindamycin 600mg hard capsules are white hard capsules marked with a724 on the cap in black ink.
Reproduction studies performed in rats and mice using oral doses of clindamycin up to 600 mg kgday 2. Buy clindamycin no prescription clindamycin 1a pharma 600. What you need to know before you take clindamycin 3. The exception is the vaginal suppository, which is not available as a generic in the usa. Dalacin c 600 mg 4 ml 1 amp price from seif in egypt. For instance, if you take 300 mg per dose, it may be significantly less expensive to take two of the 150 mg capsules, instead of one 300 mg capsule. Medscape infectionspecific dosing for cleocin, clindesse clindamycin.
For dosages that cannot be achieved with clindamycin stada 600 mg hard capsules, other pharmaceutical forms with lower dosages are available. The full name of this medicine is clindamycin 600mg hard capsules but within the leaflet it will be referred to as clindamycin. Clindamycin is available as a generic drug, for both systemic oral and intravenous and topical use. Following a 600 mg dose the absolute bioavailability is 5314%. The fleming fmtvdm directed covid19 treatment protocol. Clindamycin capsules fda prescribing information, side. For more severe infections, 300 to 450 mg every 6 hours. Cleocin pediatric clindamycin palmitate hydrochloride dose.
1317 1640 124 1558 327 1016 1443 852 751 337 1447 1309 840 998 936 1138 1347 428 1543 1638 541 1611 266 935 919 258 1301 1180 1041 1223 646 50 1463 1252